The Science Behind NAD+
Understanding what happens inside your cells — and why it matters for how you feel every day.
What is NAD+?
NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme found in every living cell in your body. It plays a central role in two critical processes: converting the food you eat into usable cellular energy, and activating proteins that support DNA repair and cellular maintenance.
Without adequate NAD+, your cells can't produce energy efficiently, repair damage, or maintain the biological processes that keep you feeling sharp and resilient. It's one of the most fundamental molecules in human biology — as essential to life as water and oxygen.
Why NAD+ levels decline with age
Research has shown that NAD+ levels decline significantly as we age. By age 50, many people have roughly half the NAD+ levels they had in their 20s. This decline is accelerated by factors like chronic stress, poor sleep, excess alcohol consumption, and sedentary lifestyles.
As NAD+ drops, so does your body's ability to perform at its best. You may notice it as afternoon energy crashes, slower recovery after exercise, difficulty concentrating, or simply feeling like your body isn't bouncing back the way it used to.
This is why researchers in the fields of longevity and cellular health have focused intensely on NAD+ — and why supplementation has become one of the most actively studied areas in wellness science.
Why three ingredients, not just one?
Most NAD+ supplements on the market deliver a single ingredient. We took a different approach. Our formula combines three clinically studied compounds that support cellular health through different mechanisms — providing more comprehensive support than any one ingredient alone.*
Ingredient Deep-Dives
NAD+ — 500mg: The foundation
NAD+ is the coenzyme your cells depend on for energy production and DNA repair. It works within the mitochondria — your cells' power generators — to convert nutrients into ATP, the energy currency your body runs on.
Our formula provides NAD+ directly, rather than relying on precursors like NMN or NR that your body must first convert. While precursor supplements are well-studied and effective, direct NAD+ supplementation offers a straightforward approach to supporting your cellular NAD+ levels.*
Key roles NAD+ plays in the body:
Quercetin — 250mg: The protector
Quercetin is a naturally occurring flavonoid found in foods like onions, apples, and berries. It has been widely studied for its role in supporting a healthy inflammatory response and optimal immune function.
In our formula, Quercetin serves a dual purpose. First, it provides antioxidant support that helps protect cells from oxidative stress — a key factor in cellular aging. Second, emerging research suggests Quercetin may act as a senolytic agent, meaning it may help the body clear damaged or dysfunctional cells that accumulate over time.*
Our Quercetin is sourced from Sophora japonica (whole flower bud), standardized for consistent potency in every capsule.
Resveratrol — 150mg: The activator
Resveratrol is a polyphenol naturally found in red grapes, berries, and peanuts. It has been extensively studied for its potential role in supporting cardiovascular health, cognitive function, and healthy aging.
One of the most compelling areas of Resveratrol research involves its relationship with sirtuins — a family of proteins sometimes called "longevity genes." Sirtuins depend on NAD+ to function, and Resveratrol appears to support sirtuin activation. This is why pairing Resveratrol with NAD+ may offer synergistic benefits that neither ingredient provides alone.*
Our Resveratrol is sourced from Japanese Knotweed (Polygonum cuspidatum) root, standardized to 98% purity — one of the highest concentrations available in supplement form.
How They Work Together
Each of our three ingredients supports cellular health, but they do so through different pathways. NAD+ fuels cellular energy and repair. Quercetin supports immune function and helps protect against oxidative damage. Resveratrol supports cardiovascular wellness and may enhance sirtuin activity.
When combined, these ingredients don't just add to each other — they complement each other. Resveratrol may help activate the very proteins that depend on NAD+ to function. Quercetin may help protect cells so that NAD+ can do its repair work more effectively. This multi-pathway approach is what sets our formula apart from single-ingredient alternatives.*
Quality & Testing
Science means nothing without quality. Every batch of Zylava NAD+ is:
We believe you deserve to know exactly what you're putting in your body. No proprietary blends. No hidden doses. No guessing.
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*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. The information on this page is for educational purposes only and is not intended as medical advice. Always consult your healthcare professional before starting any supplement regimen.
The research referenced on this page reflects the current body of publicly available scientific literature on NAD+, Quercetin, and Resveratrol. Zylava does not claim that its products will produce the same results as those observed in clinical studies. Individual results may vary.